2-Methylimidazole → 6-(2-Methyl-1H-imidazol-1-yl)-N-[(1R)-1-phenylethyl]pyrazin-2-amine

HRID 854450

Reaction equation

HRID 854450 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C@@H:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])[CH:5]=[N:4][CH:3]=1.[CH3:17][C:18]1[NH:19][CH:20]=[CH:21][N:22]=1>>[CH3:17][C:18]1[N:19]([C:2]2[N:7]=[C:6]([NH:8][C@@H:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH3:10])[CH:5]=[N:4][CH:3]=2)[CH:20]=[CH:21][N:22]=1

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 587170826-chloro-N-[(1R)-1-phenylethyl]pyrazin-2-amine

Product 1

HCID 104688356-(2-Methyl-1H-imidazol-1-yl)-N-[(1R)-1-phenylethyl]pyrazin-2-amineYield 96.2%

Procedure

In a procedure analogous to example 2, reaction of 6-chloro-N-[(1R)-1-phenylethyl]pyrazin-2-amine (150 mg, 0.64 mmol) and 2-methylimidazole (58 mg, 0.71 mmol) furnished the product (172 mg, 40%).

Sources & evidence

ORD record
ord-846c02924b314bcb98dffec6703e2b05
Source dataset
uspto-grants-2007_08
Patent number
US07259179B2

Linked notes

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