Ammonia → 4-(4-[1,2,3]Triazol-1-ylmethyl-thiazol-2-yl)-phenol

Participants

Reaction Steps

A solution of 1.36 g (5.0 mmol) 1-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-1H-[1,2,3]triazole in 100 ml 47% aqueous hydrobromic acid was stirred at 70° C. for 6 h. The reaction mixture was poured on ice, made basic with concentrated ammonia and extracted with ethyl acetate to yield 0.87 g raw product. This was purified on silica. Elution with ethyl acetate/heptane 1:1 furnished 287 mg (22%) 4-(4-[1,2,3]triazol-1-ylmethyl-thiazol-2-yl) -phenol as white crystals, melting at 164-166° C.

Provenance & Evidence