Ethyl (2E)-4,4,4-trifluoro-2-butenoate → ethyl 7-isopropyl-2-(trifluoromethyl)-2H-chromene-3-carboxylate
Reaction equation
[OH:1][C:2]1[CH:9]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH2:13]([O:15][C:16](=[O:23])/[CH:17]=[CH:18]/[C:19]([F:22])([F:21])[F:20])[CH3:14]>>[CH:10]([C:8]1[CH:9]=[C:2]2[C:3]([CH:4]=[C:17]([C:16]([O:15][CH2:13][CH3:14])=[O:23])[CH:18]([C:19]([F:20])([F:22])[F:21])[O:1]2)=[CH:6][CH:7]=1)([CH3:12])[CH3:11]Participants
3
Procedure
This salicylaldehyde (Step 1) was condensed with Ethyl-4,4,4-triflurocrotonate via a similar method to that of Example 4a, Step 1 producing the ethyl ester (8.21 g, 84%) as yellow solid. This ester was of suitable purity to use without further purification: ESLRMS m/z 315 (M+H).
Workup
- customto use without further purification
Sources & evidence
- ORD record
- ord-09b32436f2ea4b819efcedb1dfc9c4f0