3-Methyl-1-butene → ethyl 7-(3-methylbutyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

HRID 855086

Reaction equation

HRID 855086 reaction equation
I[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:8]([C:12]([F:15])([F:14])[F:13])[O:9]2)=[CH:4][CH:3]=1.[CH3:21][CH:22]([CH3:25])[CH:23]=[CH2:24]>>[CH3:21][CH:22]([CH3:25])[CH2:23][CH2:24][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:8]([C:12]([F:15])([F:14])[F:13])[O:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 112393-Methyl-1-buteneHCID 69517680ethyl 7-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Product 1

HCID 69518920ethyl 7-(3-methylbutyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Procedure

The ester from Example 9a, Step 2 was coupled and using a similar protocol as described in Example 611d, Step 1 using the appropriate substitution of 3-methylbut-1-ene (77%): ESLRMS m/z 343.1 (M+H).

Sources & evidence

ORD record
ord-66807ae13e854cdd8030895bf5808e80
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Linked notes

Loading…