Phenethylamine, m-trifluoromethyl- → [4-(1-Methoxycyclobutyl)-benzyl]-[2-(3-trifluoromethylphenyl)-ethyl]-amine

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Reaction Steps

The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 4-(1-methoxycyclobutyl)-benzaldehyde (76 mg, 0.40 mmol), 2-(3-trifluoromethylphenyl)-ethylamine (76 mg, 0.40 mmol) and sodium borohydride (17 mg, 0.44 mmol). The isolated residue was purified by flash column chromatography (2%-5% MeOH in EtOAc) to give the desired product (112 mg, 77%) as a colorless oil. MS (ISP) 364.3 (M+H)+.

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