Mannitol → Fentanyl

HRID 8554

Reaction equation

HRID 8554 reaction equation
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.[CH3:13][CH2:14][C:15]([N:17]([CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:26][CH2:25]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:16].C(C(O)(C(O)=O)CC(O)=O)C(O)=O.COC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC1C=CC=CC=1)=O>O>[CH3:13][CH2:14][C:15]([N:17]([CH:24]1[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:28][CH2:29]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:16]

Participants

5

Reactant 3

HCID 6251MannitolHCID 13810Fentanyl CitrateHCID 134601Aspartame

Product 1

HCID 3345Fentanyl

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Gelatin (765 g) and mannitol (540 g) were dispersed in a portion of purified water (16 kg) by mixing thoroughly in the bowl of a vacuum mixer. The mix was then heated to 40° C.±2° C. and homogenised for ten minutes to allow complete dissolution of the solids. The mix was cooled down to room temperature (20–24° C.). When cooled, the fentanyl citrate (22.68 g), the aspartame (90 g), and mint flavour (90 g) were added sequentially to the mix. The mix was then homogenized to ensure complete dissolution of the solids. The remaining water (492 g) was added to the mixer and the bulk mix homogenized to ensure dissolution was complete.

Workup

  1. additionby mixing thoroughly in the bowl of a vacuum mixer
  2. temperatureThe mix was then heated to 40° C.±2° C.
  3. dissolutiondissolution of the solids
  4. temperatureWhen cooled
  5. stirringThe mix was then homogenized
  6. dissolutiondissolution of the solids
  7. additionthe bulk mix
  8. stirringhomogenized
  9. dissolutiondissolution

Sources & evidence

ORD record
ord-7699baaddd76414b851d402dc61a2e83
Source dataset
uspto-grants-2006_08
Patent number
US07090866B2

Linked notes

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