HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 5-[2-(tert-butoxycarbonylmethylamino)acetylamino]benzofuran-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- | HCID 83692 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | Ethyl 5-aminobenzofuran-2-carboxylate | HCID 9837138 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 5-[2-(tert-butoxycarbonylmethylamino)acetylamino]benzofuran-2-carboxylate | HCID 69145149 | — |
Reaction Steps
50 ml of DMF are added to 0.95 g of Boc-sarcosine and 1.21 g of ethyl 5-aminobenzofuran-2-carboxylate. 1.77 g of TBTU and 0.23 g of HOBt are then added, and the mixture is neutralised using 4 ml of triethylamine. The mixture is stirred overnight at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262216B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-e8643fa016cd4d64a8adc826c5fc6cb3 |
| Source note | uspto-grants-2007_08 |