Diethyl Ether → (2R,3S)-3-amino-2-hydroxy-4-phenylbutyl(3-methoxybenzyl)carbamate hydrochloride

Participants

Reaction Steps

1-tert-butyl (1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate (XXXIV, EXAMPLE 5, 5.4 g) and dioxane-hydrochloric acid (20 ml, 4 N) are mixed. The reaction mixture is stirred at 20–25° for 30 minutes then poured into stirred ether (300 ml). The product is filtered and dried under reduced pressure to give the title compound, M+H=435.

Provenance & Evidence