HCID 21864153, compound → HCID 14185044, compound

Reaction equation

C([O:3][C:4]([C:6]1(C(OCC)=O)[CH:10]([CH3:11])[CH2:9][CH2:8][NH:7]1)=[O:5])C.CC1(C)CCNC1C(O)=O.C(C1(C(OCC)=O)C(C)(C)CCN1)(OCC)=O>>[CH3:11][C@@H:10]1[CH2:9][CH2:8][NH:7][C@H:6]1[C:4]([OH:5])=[O:3]

Participants

Reactant 3

HCID 21864153HCID 21864153, compound

HCID 21866189Diethyl 3,3-dimethylpyrrolidine-2,2-dicarboxylate

HCID 21866212HCID 21866212, compound

Product 1

HCID 14185044HCID 14185044, compound

Procedure

The title compound was prepared by acidic hydrolysis of diethyl-3-methylpyrrolidine-2,2-dicarboxylate according to the procedure described in Morgan, B. A.; Schafer, D. J. U.S. Pat. No. 4,060,603 for the preparation of 3,3-dimethyl-dl-proline from 2,2-dicarboethoxy-3,3-dimethylpyrrolidine.

Sources & evidence

ORD record: ord-44281647119f4c45a518afc96214161f
Source dataset: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07144899B2

Reaction notes

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