Chlorosulfonic acid → HCID 58762874, compound

Reaction equation

[CH3:1][C:2]1[C:10]2[O:9][C:8](=[O:11])[NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl[S:13]([OH:16])(=[O:15])=[O:14]>>[CH3:1][C:2]1[C:10]2[O:9][C:8](=[O:11])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[S:13]([OH:16])(=[O:15])=[O:14]

Participants

Reactant 2

HCID 24638Chlorosulfonic acid

HCID 117447917-methyl-3H-benzooxazol-2-one

Product 1

HCID 58762874HCID 58762874, compoundYield 60%

Procedure

7-Methyl-3H-benzooxazol-2-one [5.0 g, 33 mmol, prepared according to the procedure described in J. Org. Chem. (1982), 47(14), 2804–6) was treated with chlorosulphonic acid as described in Example 15 (i) to give the title compound as an off-white solid (4.5 g, 60%).

Sources & evidence

ORD record: ord-c3aeb38733d7405a88f0b9ff2a424dc2
Source dataset: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07148236B2

Reaction notes

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