2-Bromophenol → 1-Bromo-2-(methoxymethoxy)benzene
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[CH3:9][O:10][CH2:11]Cl>>[CH3:9][O:10][CH2:11][O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Br:1]Participants
3
Procedure
In a manner similar to that of Example 7(a), by reaction of 15.00 g (86.7 mmol) of 2-bromophenol with 8.40 g (104.0 mmol) of chloromethyl methyl ether, 18.80 g (100%) of the expected product are obtained in the form of a beige-coloured oil.
Sources & evidence
- ORD record
- ord-58afa00ea6f74103a5f4de30c284e8eb
- Source dataset
- uspto-grants-2006_12
- Patent number
- US07148245B2
Reaction notes
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