4'-Chloro-3'-nitroacetophenone → 1-[4-({4-[(2S)-2-hydroxypropyl]phenyl}amino)-3-nitrophenyl]ethanone

HRID 858490

Reaction equation

HRID 858490 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C@@H:22]([OH:24])[CH3:23])=[CH:17][CH:16]=1>>[OH:24][C@@H:22]([CH3:23])[CH2:21][C:18]1[CH:19]=[CH:20][C:15]([NH:14][C:2]2[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=2[N+:11]([O-:13])=[O:12])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 795964'-Chloro-3'-nitroacetophenoneHCID 67099494(S)-1-(4-aminophenyl)propan-2-ol

Product 1

HCID 670993891-[4-({4-[(2S)-2-hydroxypropyl]phenyl}amino)-3-nitrophenyl]ethanone

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 162 from 1-(4-chloro-3-nitrophenyl)ethanone and (2S)-i-(4-aminophenyl)-2-propanol (step 2).

Sources & evidence

ORD record
ord-a3fcf0e2857444a385c69eccdda68ea1
Source dataset
uspto-grants-2006_12
Patent number
US07148234B2

Linked notes

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