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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 859Generated: October 23, 2026

4-Piperidineethanol → benzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamate

https://huagongshe.com/en/reaction/859

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-PiperidineethanolHCID 73953—
ReactantBenzyl [amino(methylsulfanyl)methylene]carbamateHCID 140362141—
SolventAcetonitrileHCID 6342—
Productbenzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamateHCID 14037907841%

Reaction Steps

A mixture of 6.2 g (0.028 mol) of 4-hydroxyethyl piperidine and 3.6 g (0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05723444
Source datasetuspto-grants-1998_03
ORD IDord-38cb457f7729445685e412a4fffa8894
Source noteuspto-grants-1998_03