tert-Butyl N-[4-(4-chlorophenyl)-2-nitro-phenyl]carbamate → tert-butyl N-[2-amino-4-(4-chlorophenyl)phenyl]carbamate

HRID 859309

Reaction equation

HRID 859309 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Zn].[NH4+].[Cl-]>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69592790tert-Butyl N-[4-(4-chlorophenyl)-2-nitro-phenyl]carbamate

Product 1

HCID 69592781tert-butyl N-[2-amino-4-(4-chlorophenyl)phenyl]carbamate

Reagents, catalysts & solvents 1

HCID 5362536Azanium ZINC chlorideCatalyst

Procedure

Prepared from (4′-chloro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example C2) by reduction with Zn/NH4Cl according to the general procedure G (method c). Obtained as a green solid (162 mg).

Sources & evidence

ORD record
ord-34f7996357974520a74c91faddd3cfd8
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Linked notes

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