Diethyl Ether → Benzyl 3-(1-hydroxyethyl)piperidine-1-carboxylate

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH2:12][CH:13]([CH:17]=[O:18])[CH2:14][CH2:15][CH2:16]1.[CH3:19][CH2:20][O:21][CH2:22][CH3:23].[CH3:24][CH:25]([CH3:26])[O-:27].[CH3:28][CH:29]([CH3:30])[O-:31].[CH3:32][CH:33]([CH3:34])[O-:35].[CH3:36][CH:37]([CH3:38])[O-:39].[Ti+4:40]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH2:12][CH:13]([CH:17]([OH:18])[CH3:19])[CH2:14][CH2:15][CH2:16]1

Participants

Reactant 4

HCID 3283Diethyl Ether

HCID 114942Titanium cation (4+)

HCID 3260420Isopropanolate4×

HCID 9899653Benzyl 3-formylpiperidine-1-carboxylate

Product 1

HCID 18332640Benzyl 3-(1-hydroxyethyl)piperidine-1-carboxylate

Sources & evidence

ORD record: ord-41fd4bb9c8124d60b11cf1bada4e5f8f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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