Cyclohexylmethane sulfonyl chloride → C-Cyclohexyl-N-{4-[4-(3-dimethylamino-phenyl)-piperazin-1-yl]-butyl}-methanesulfonamide

HRID 859909

Reaction equation

HRID 859909 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[C:14]([N:18]([CH3:20])[CH3:19])[CH:15]=[CH:16][CH:17]=2)[CH2:8][CH2:7]1.[CH:21]1([CH2:27][S:28](Cl)(=[O:30])=[O:29])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[CH:21]1([CH2:27][S:28]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[CH2:11][CH2:10][N:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([N:18]([CH3:20])[CH3:19])[CH:13]=3)[CH2:8][CH2:7]2)(=[O:30])=[O:29])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 3871475Cyclohexylmethane sulfonyl chlorideHCID 68824299{3-[4-(4-Amino-butyl)-piperazin-1-yl]-phenyl}-dimethyl-amine

Product 1

HCID 10094582C-Cyclohexyl-N-{4-[4-(3-dimethylamino-phenyl)-piperazin-1-yl]-butyl}-methanesulfonamide

Procedure

Reaction of {3-[4-(4-amino-butyl)-piperazin-1-yl]-phenyl}-dimethyl-amine and cyclohexyl-methanesulfonyl chloride as described in Preparation 8 gave desired compound, C-Cyclohexyl-N-{4-[4-(3-dimethylamino-phenyl)-piperazin-1-yl]-butyl}-methanesulfonamide.

Workup

  1. customas described in Preparation 8

Sources & evidence

ORD record
ord-0389a063eefe436e8c6b81c937b8c5f5
Source dataset
uspto-grants-2006_12
Patent number
US07153858B2

Linked notes

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