2,5-Dimethoxytetrahydrofuran → HCID 22097215, compound
Reaction equation
[C:1]([NH:4][C:5]1[C:10]([NH:11][C:12](=[O:14])[CH3:13])=[CH:9][C:8]([Cl:15])=[C:7]([NH2:16])[CH:6]=1)(=[O:3])[CH3:2].CO[CH:19]1[CH2:23][CH2:22][CH:21](OC)O1>C(O)(=O)C>[Cl:15][C:8]1[CH:9]=[C:10]([NH:11][C:12](=[O:14])[CH3:13])[C:5]([NH:4][C:1](=[O:3])[CH3:2])=[CH:6][C:7]=1[N:16]1[CH:19]=[CH:23][CH:22]=[CH:21]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3 g (12.4 mmol) of 4,5-diacetamido-2-amino-1-chlorobenzene and 1.6 g (12.4 mmol) of 2,5-dimethoxytetrahydrofuran in 150 ml of acetic acid were refluxed for 30 minutes. The reaction mixture was concentrated, the residue was washed with water and ethyl acetate, and the organic phase was worked up.
Workup
- concentration