3,4,5-Trimethoxybenzonitrile → 3,4,5-Trimethoxybenzylamine

HRID 861629

Reaction equation

HRID 861629 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[C:6]#[N:7].[BH4-].[Na+]>[Co](Cl)Cl>[CH3:14][O:13][C:9]1[CH:8]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:10]=1[O:11][CH3:12])[CH2:6][NH2:7]

Participants

4

Reactant 2

HCID 158923,4,5-TrimethoxybenzonitrileHCID 4311764Sodium borohydride

Product 1

HCID 877363,4,5-Trimethoxybenzylamine

Reagents, catalysts & solvents 1

HCID 24288Cobalt(II) chlorideCatalyst

Procedure

The starting material 3,4,5-trimethoxybenzylamine was prepared by reduction of 3,4,5-trimethoxybenzonitrile with cobalt chloride and sodium borohydride, according to the general method described by L. S. Heinzman in J. Am. Chem. Soc., 104, p. 6801 (1980).

Sources & evidence

ORD record
ord-883ddb307ba34f90bf8f311d39d8014a
Source dataset
uspto-grants-1998_02
Patent number
US05714503

Linked notes

Loading…