4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)piperidine → 1-(2-Benzyloxycarbonylaminoacetyl)-4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine

HRID 861758

Reaction equation

HRID 861758 reaction equation
[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[C:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:22]([O:29][C:30]([NH:32][CH2:33][C:34](Cl)=[O:35])=[O:31])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([O:29][C:30]([NH:32][CH2:33][C:34]([N:19]1[CH2:18][CH2:17][C:16](=[C:6]2[C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[CH:9]=[CH:10][C:11]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]2=3)[CH2:21][CH2:20]1)=[O:35])=[O:31])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 1597184-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)piperidineHCID 12239759Benzyloxycarbonylaminoacetyl chloride

Product 1

HCID 197032431-(2-Benzyloxycarbonylaminoacetyl)-4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidineYield 61%

Procedure

The title compound, a white crystalline, was prepared by acylation of 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine with N-benzyloxycarbonylglycine chloride in a similar way as described under Example 19. Yield: 61%

Sources & evidence

ORD record
ord-dd3fde1c5ed34b2ca753b1bc1ccc1547
Source dataset
uspto-grants-1998_02
Patent number
US05714501

Linked notes

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