2-Ethyl-2-methyl-1,3-propanediol → 5-Ethyl-5-methyl-2-(4-nitrobenzyl)-1,3,2-dioxaphosphorinan-2-oxide

HRID 861874

Reaction equation

HRID 861874 reaction equation
[N+:1]([C:4]1[CH:14]=[CH:13][C:7]([CH2:8][P:9](=[O:12])([OH:11])[OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:15]([C:17]([CH3:22])([CH2:20]O)[CH2:18]O)[CH3:16]>>[CH2:15]([C:17]1([CH3:22])[CH2:20][O:11][P:9](=[O:10])([CH2:8][C:7]2[CH:13]=[CH:14][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[O:12][CH2:18]1)[CH3:16]

Participants

3

Reactant 2

HCID 661692-Ethyl-2-methyl-1,3-propanediolHCID 5180708(4-Nitro-benzyl)-phosphonic acid

Product 1

HCID 189280695-Ethyl-5-methyl-2-(4-nitrobenzyl)-1,3,2-dioxaphosphorinan-2-oxide

Procedure

4-Nitrobenzylphosphonic acid and 2-ethyl-2-methyl-1,3-propanediol were treated in the same manner as in Reference Example 20 to yield 5-ethyl-5-methyl-2-(4-nitrobenzyl)-1,3,2-dioxaphosphorinan-2-oxide, which was then recrystallized from ethanol-hexane to yield colorless prisms having a melting point of 184°-185° C.

Sources & evidence

ORD record
ord-323aa9894e77450aaff35420e7dc5495
Source dataset
uspto-grants-1998_02
Patent number
US05716944

Linked notes

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