2-Fluorobenzophenone → (2-Fluorophenyl)(phenyl)methanol

HRID 861901

Reaction equation

HRID 861901 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>C(O)C>[F:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH:4]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[OH:5]

Participants

4

Reactant 2

HCID 676502-FluorobenzophenoneHCID 4311764Sodium borohydride

Product 1

HCID 10584252(2-Fluorophenyl)(phenyl)methanolYield 99%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Fluorobenzophenone (15.0 g) is dissolved in ethanol and sodium borohydride (3.8 g) is added in portions and the mixture is stirred for 20 hours. The reacted solution is concentrated under reduced pressure and extracted with chloroform and water to give crude (2-fluorophenyl)phenylmethanol (15.0 g) (quantitative) as colorless liquid.

Workup

  1. concentrationThe reacted solution is concentrated under reduced pressure
  2. extractionextracted with chloroform and water

Sources & evidence

ORD record
ord-c9141cfb5aeb445e97fcde16004fb780
Source dataset
uspto-grants-1998_02
Patent number
US05716950

Linked notes

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