Reaction equation
[N+:1]([O-:4])(O)=[O:2].S(=O)(=O)(O)O.[F:10][C:11]([F:23])([F:22])[O:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[C:16]([OH:18])=[O:17]>>[N+:1]([C:19]1[CH:20]=[CH:21][C:13]([O:12][C:11]([F:10])([F:23])[F:22])=[CH:14][C:15]=1[C:16]([OH:18])=[O:17])([O-:4])=[O:2]Participants
4
Procedure
29.7 ml of nitric acid were added dropwise to 76.5 ml of concentrated sulfuric acid, while cooling and stirring, and 9.0 g (43.7 mmol) of 3-trifluoromethoxybenzoic acid were then added. The reaction mixture was heated at 50°-55° C. for 1 hour and, after cooling, was poured onto ice, and the residue was filtered off with suction to give, after drying, 8.8 g of product, melting point 90°-93° C. (sintering at 85° C.).
Workup
- temperaturewhile cooling
- temperatureThe reaction mixture was heated at 50°-55° C. for 1 hour
- temperatureafter cooling
- additionwas poured onto ice
- filtrationthe residue was filtered off with suction
- customto give
- customafter drying
- custom8.8 g of product, melting point 90°-93° C. (sintering at 85° C.)
Sources & evidence
- ORD record
- ord-7f0d81cb2cac4dca8001c7cc3afd530e
- Source dataset
- uspto-grants-1998_02
- Patent number
- US05719164
Linked notes
Loading…