Isopropyl iodide → 2-Nitro-5-(2-propyloxy)benzyl alcohol

HRID 862667

Reaction equation

[OH:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH2:7][OH:8].[CH:13](I)([CH3:15])[CH3:14]>>[N+:10]([C:5]1[CH:4]=[CH:3][C:2]([O:1][CH:13]([CH3:15])[CH3:14])=[CH:9][C:6]=1[CH2:7][OH:8])([O-:12])=[O:11]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 1089463-(Hydroxymethyl)-4-nitrophenol

Product 1

HCID 544873402-Nitro-5-(2-propyloxy)benzyl alcohol

Procedure

10 g (60 mmol) of 5-hydroxy-2-nitrobenzyl alcohol were reacted with 7.0 ml (70 mmol) of isopropyl iodide analogously to Example 4a); after purification over silica gel with n-heptane/ethyl acetate (3:2), 10.3 g of oily crude product.

Workup

customafter purification over silica gel with n-heptane/ethyl acetate (3:2), 10.3 g of oily crude product

Sources & evidence

ORD record: ord-b7f99e2042554d2789c4539143f2549a
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05719164

Linked notes

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