Hexane → 4-[([1,1'-Biphenyl]-2-carbonyl)amino]-3-methoxybenzoyl chloride
Reaction equation
[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:2]([C:7]([NH:9][C:10]2[CH:18]=[CH:17][C:13]([C:14](O)=[O:15])=[CH:12][C:11]=2[O:19][CH3:20])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.CCCCCC.S(Cl)([Cl:35])=O>>[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:2]([C:7]([NH:9][C:10]2[CH:18]=[CH:17][C:13]([C:14]([Cl:35])=[O:15])=[CH:12][C:11]=2[O:19][CH3:20])=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1Participants
4
Procedure
A solution of 2.69 g of 4-[([1,1'-biphenyl]-2-carbonyl]amino]-3-methoxy benzoic acid in 5 ml of thionyl chloride is heated on a steam bath for 1 hour under Argon. The volatiles are removed in vacuo to give a residue which is stirred with hexane to give 2.58 g of crystalline solid, m.p. 121°-123° C. M+ =361.
Workup
- customThe volatiles are removed in vacuo