Benzenepropanoic acid, 4-hydroxy-, methyl ester → Methyl 3-[4-[1-(4-pyridyl)piperidin-4-yl]methoxyphenyl]propionate

HRID 864836

Reaction equation

HRID 864836 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH2:5][CH2:4]1.O[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[CH:18][CH:17]=1>>[N:12]1[CH:13]=[CH:14][C:9]([N:6]2[CH2:5][CH2:4][CH:3]([CH2:2][O:1][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[CH:18][CH:17]=3)[CH2:8][CH2:7]2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 79706Benzenepropanoic acid, 4-hydroxy-, methyl esterHCID 11310048(1-(Pyridin-4-YL)piperidin-4-YL)methanol

Product 1

HCID 18918568Methyl 3-[4-[1-(4-pyridyl)piperidin-4-yl]methoxyphenyl]propionateYield 14%

Procedure

Following the method of Example 155, but starting from 4-(4-hydroxymethylpiperidin-1-yl)pyridine and methyl 3-(4-hydroxyphenyl)propionate, the title compound was prepared in 14% yield:

Sources & evidence

ORD record
ord-3af6014d57c742cfb5788614fe0af40d
Source dataset
uspto-grants-1996_10
Patent number
US05563141

Linked notes

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