HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → 2,6-Dipropyl-4-(2-hydroxyethyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | t-Butyldimethylsilyloxy-2,6-dipropyl-4-(2-hydroxyethyl)-benzene | HCID 19080442 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2,6-Dipropyl-4-(2-hydroxyethyl)phenol | HCID 19080373 | — |
Reaction Steps
To a solution of 1.0 g (2.98 mrnol) of the product of Step C in 3.0 mL of THF was added 3.57 mL (3.57 mmol) of 1.0 N solution of tetrabutylammonium fluoride in THF. After 15 minutes TLC indicated that the reaction was complete. The reaction mixture was concentrated and then purified by flash chromatography (silica gel, hexane/ethyl acetate 3:1) to give 1.13 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05565485 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-358f89dd7cad4de78ad84ce485f328f1 |
| Source note | uspto-grants-1996_10 |