Ethyl 4-amino-1-piperidinecarboxylate → HCID 23374509, compound

HRID 865647

Reaction equation

HRID 865647 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4][CH2:3]1.C(O[C:16]1[CH:21]=[CH:20][N:19]=[CH:18][C:17]=1[N+:22]([O-:24])=[O:23])C>CC#N>[N+:22]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][C:16]=1[NH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:6][CH2:7]1)([O-:24])=[O:23]

Participants

4

Reactant 2

HCID 100867Ethyl 4-amino-1-piperidinecarboxylateHCID 3563054-Ethoxy-3-nitropyridine

Product 1

HCID 23374509HCID 23374509, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of ethyl 4-amino-1-piperidinecarboxylate (3.53 g, 20.5 mmol) and 4-ethoxy-3-nitropyridine (3.65 g, 21/7 mmol) in CH3CN (25 mL) was heated at reflux for 40 hours. The reaction mixture was cooled to ambient temperature and concentrated in vacuo to give an orange syrup which was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 40 hours
  3. concentrationconcentrated in vacuo
  4. customto give an orange syrup which
  5. customwas used without further purification

Sources & evidence

ORD record
ord-5b8ae9819dc8446a9b95b612a6523f32
Source dataset
uspto-grants-1996_10
Patent number
US05567711

Linked notes

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