Dimethylamine → 4-acetyl-N,N-dimethylbenzene-1-sulfonamide

HRID 866973

Reaction equation

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C(C1C=CC(S([O-])(=O)=O)=CC=1)(=O)C.[Na+].[CH3:28][NH:29][CH3:30].C(C1C=CC(S(N)(=O)=O)=CC=1)(=O)C>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:29]([CH3:30])[CH3:28])(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]

Participants

Reactant 4

HCID 674Dimethylamine

HCID 740654-Acetylbenzenesulphonamide

HCID 2664184-Acetylbenzenesulfonyl chloride

HCID 23668814Sodium 4-acetylbenzenesulphonate

Product 1

HCID 20640414-acetyl-N,N-dimethylbenzene-1-sulfonamide

Procedure

From the damp 4-acetylbenzenesulfonyl chloride from 200 g. of sodium 4-acetylbenzenesulfonate, and 1 l. of 20% aqueous dimethylamine, following the procedure of (c) above, there is obtained 4-acetyl-N,N-dimethylbenzenesulfonamide; m.p. 97°-99° C. after crystallization from aqueous ethanol.

Sources & evidence

ORD record: ord-0f5ba4f2f48c4b6e94b64d70bbd582b5
Source dataset: uspto-grants-1978_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04101661

Linked notes

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