Hydrazine → 2,4-Dimethylbenzohydrazide
Reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4](OC)=[O:5].[NH2:13][NH2:14]>CO>[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4]([NH:13][NH2:14])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of methyl 2,4-dimethylbenzoate (2 g, 12.2 mmol) in MeOH (10 mL) was added anhydrous hydrazine (1.95 mL, 61 mmol) and the mixture was heated under reflux for 40 hours. Then the mixture was evaporated and dried under vacuum to give 2,4-dimethylbenzohydrazide as a white solid (2 g, 100%; MS (M+H, 165).
Workup
- temperaturethe mixture was heated
- temperatureunder reflux for 40 hours
- customThen the mixture was evaporated
- customdried under vacuum
Sources & evidence
- ORD record
- ord-f378556826b04b0b900242b1ebc2cb1b
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08968708B2
Reaction notes
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