Hydrazine → 2,4-Dimethylbenzohydrazide

HRID 868751Notes

Reaction equation

HRID 868751 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4](OC)=[O:5].[NH2:13][NH2:14]>CO>[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4]([NH:13][NH2:14])=[O:5]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 32031Methyl 2,4-dimethylbenzoate

Product 1

HCID 48461732,4-Dimethylbenzohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 2,4-dimethylbenzoate (2 g, 12.2 mmol) in MeOH (10 mL) was added anhydrous hydrazine (1.95 mL, 61 mmol) and the mixture was heated under reflux for 40 hours. Then the mixture was evaporated and dried under vacuum to give 2,4-dimethylbenzohydrazide as a white solid (2 g, 100%; MS (M+H, 165).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 40 hours
  3. customThen the mixture was evaporated
  4. customdried under vacuum

Sources & evidence

ORD record
ord-f378556826b04b0b900242b1ebc2cb1b
Source dataset
uspto-grants-2015_03
Patent number
US08968708B2

Reaction notes

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