2-(4-Methylmorpholin-2-yl)ethan-1-ol → HCID 86723163, compound

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[I:11].[CH3:12][N:13]1[CH2:18][CH2:17][O:16][CH:15]([CH2:19][CH2:20]O)[CH2:14]1>>[I:11][C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)[N:7]([CH2:20][CH2:19][CH:15]2[O:16][CH2:17][CH2:18][N:13]([CH3:12])[CH2:14]2)[N:6]=1

Participants

Reactant 2

HCID 213028482-(4-Methylmorpholin-2-yl)ethan-1-ol

HCID 178505475HCID 178505475, compound

Product 1

HCID 86723163HCID 86723163, compoundYield 80%

Procedure

The title compound was prepared from 5-fluoro-3-iodo-indazole and 2-(4-methylmorpholin-2-yl)ethanol in 80% yield according to the general procedure for Preparation 31A. The minor isomer was not isolated or characterized.

Workup

customThe minor isomer was not isolated

Sources & evidence

ORD record: ord-ca17bff58f4040f4894acbdf13447641
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08969343B2

Reaction notes

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