HCID 178470236, compound → HCID 178524884, compound
Reaction equation
[F:1][C:2]([F:30])([F:29])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([N:11]2[CH2:15][CH2:14][CH2:13][CH:12]2COC2C(C(OCC)=O)=NC=CC=2)=[O:10])[CH2:5][CH2:4]1.CO[C:33]1[CH:34]=[C:35]([O:44][CH2:45][C@H]2CCCN2C([C@H]2CC[C@H](C(F)(F)F)CC2)=O)[C:36]([C:39]([O:41]CC)=[O:40])=[N:37][CH:38]=1>>[F:30][C:2]([F:1])([F:29])[C@H:3]1[CH2:4][CH2:5][C@H:6]([C:9]([N:11]2[CH2:12][CH2:13][CH:14]([CH2:45][O:44][C:35]3[C:36]([C:39]([OH:41])=[O:40])=[N:37][CH:38]=[CH:33][CH:34]=3)[CH2:15]2)=[O:10])[CH2:7][CH2:8]1Participants
3
Procedure
The title compound was prepared according to the procedure described in Step 4 of EXAMPLE 31 using ethyl 3-((1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-3-yl)methoxy)picolinate (EXAMPLE 92 Step 3) in stead of ethyl 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinate.
Sources & evidence
- ORD record
- ord-a2519661683c4849bd4779711f6c7b66
- Source dataset
- uspto-grants-2015_03