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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 87Generated: October 23, 2026

(2S)-2-aminopentan-1-ol → 2-[4-[[2-amino-4-[[(2S)-1-hydroxypentan-2-yl]amino]-6-methylpyrimidin-5-yl]methyl]phenyl]acetonitrile

https://huagongshe.com/en/reaction/87

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S)-2-aminopentan-1-olHCID 6951248—
Reactant2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrileHCID 87444782—
ReagentPotassium CarbonateHCID 11430—
Catalyst1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 636044—
CatalystPalladium (II) acetateHCID 4144353—
Solvent1,4-DioxaneHCID 31275—
Product2-[4-[[2-amino-4-[[(2S)-1-hydroxypentan-2-yl]amino]-6-methylpyrimidin-5-yl]methyl]phenyl]acetonitrileHCID 689557740%

Reaction Conditions

Temperature100 °C

Reaction Steps

Palladium(II) acetate (8.23 mg, 0.04 mmol) and 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene (42.4 mg, 0.07 mmol) were added to dioxane (3 mL) and the solution was stirred at room temperature for 10 minutes. 2-(4-((2-amino-4-chloro-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile (200 mg, 0.73 mmol), (S)-(+)-2-Amino-1-pentanol (151 mg, 1.47 mmol) and POTASSIUM CARBONATE (203 mg, 1.47 mmol) were added and the mixture was heated at 100 °C for 15 hours. LCMS showed no product and reaction not progressed.

Provenance & Evidence

Source dataset750 AstraZeneca ELN dataset
ORD IDord-d1855bc74886445fbdfc0eab57bed8cb
Source note750 AstraZeneca ELN dataset