3-Fluorobenzylic alcohol → 6-bromo-5-fluoro-1-(3-fluorobenzyl)-1H-indole
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]O.[Br:10][C:11]1[CH:19]=[C:18]2[C:14]([CH:15]=[CH:16][NH:17]2)=[CH:13][C:12]=1[F:20].BrC1C=C2C(C(C#N)=CN2)=CC=1>>[Br:10][C:11]1[CH:19]=[C:18]2[C:14]([CH:15]=[CH:16][N:17]2[CH2:5][C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[CH:3]=2)=[CH:13][C:12]=1[F:20]Participants
4
Procedure
The title compound was prepared using the procedure described in Example 3A using 3-fluorobenzyl alcohol and 6-bromo-5-fluoro-1H-indole in place of benzyl alcohol and 6-bromo-1H-indole-3-carbonitrile, respectively. LCMS: 323.8 (M+H)+.
Sources & evidence
- ORD record
- ord-5bf9c962439341e2aab5259b830cdd92
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08969375B2
Reaction notes
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