1-(2-Methoxyphenyl)piperazine → (3-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone

HRID 87111

Reaction equation

HRID 87111 reaction equation
[CH3:32][O:33][c:34]1[c:35]([N:40]2[CH2:41][CH2:42][NH:43][CH2:44][CH2:45]2)[cH:36][cH:37][cH:38][cH:39]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:28]([F:29])([F:30])[F:31])[c:6]([CH2:7][N:8]2[c:9]3[c:10]([n:14][cH:15][c:16](-[c:18]4[cH:19][c:20]([C:21](=[O:22])[OH:23])[cH:24][cH:25][cH:26]4)[cH:17]3)[NH:11][CH2:12][CH2:13]2)[cH:27]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:28]([F:29])([F:30])[F:31])[c:6]([CH2:7][N:8]2[c:9]3[c:10]([n:14][cH:15][c:16](-[c:18]4[cH:19][c:20]([C:21](=[O:22])[N:43]5[CH2:42][CH2:41][N:40]([c:35]6[c:34]([O:33][CH3:32])[cH:39][cH:38][cH:37][cH:36]6)[CH2:45][CH2:44]5)[cH:24][cH:25][cH:26]4)[cH:17]3)[NH:11][CH2:12][CH2:13]2)[cH:27]1

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 583278073-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid

Product 1

HCID 58327856(3-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}phenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone

Sources & evidence

ORD record
ord-d4ac56885d9947f1a24ae09c33532a78
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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