Risedronate → Phosphate

HRID 871802

Reaction equation

HRID 871802 reaction equation
[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:14]([OH:17])([OH:16])=[O:15])([P:10]([OH:13])([OH:12])=[O:11])[OH:9])[CH:2]=1.[P:18]([O-:22])([O-:21])([O-:20])=[O:19].[Ca+2].P([O-])([O-])([O-])=O.[Ca+2].[Ca+2].[OH-].[Na+].C1C=NC=C(CC(P(O)(O)=O)(P(O)(O)=O)O)C=1>O>[CH:1]1[CH:6]=[N:5][CH:4]=[C:3]([CH2:7][C:8]([P:10]([OH:12])([OH:13])=[O:11])([P:14]([OH:17])([OH:16])=[O:15])[OH:9])[CH:2]=1.[P:18]([O-:22])([O-:21])([O-:20])=[O:19]

Participants

6

Reactant 3

HCID 5245RisedronateHCID 14798Sodium HydroxideHCID 131732542HCID 131732542, compound

Product 2

HCID 1061PhosphateHCID 5245Risedronate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The risedronate-calcium-phosphate solution and 0.5N sodium hydroxide were simultaneously added to 100 mL water to maintain the pH at 7.00 until all the risedronate had been added. The precipitate was collected by filtration and washed with water. The solid was dried in an oven at 105° C. 3.93 g of calcium complex salt of Risedronate with phosphate were thus obtained.

Workup

  1. additionhad been added
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customThe solid was dried in an oven at 105° C

Sources & evidence

ORD record
ord-0a522a8974974305a5371efb11cab55e
Source dataset
uspto-grants-2015_03
Patent number
US08974801B2

Linked notes

Loading…