2-Fluoro-5-formylbenzonitrile → Benzonitrile, 5-formyl-2-[[2-(trifluoromethyl)-4-pyridinyl]oxy]-

Reaction equation

F[C:2]1[CH:9]=[CH:8][C:7]([CH:10]=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[F:12][C:13]([F:22])([F:21])[C:14]1[CH:19]=[C:18]([OH:20])[CH:17]=[CH:16][N:15]=1>>[CH:10]([C:7]1[CH:8]=[CH:9][C:2]([O:20][C:18]2[CH:17]=[CH:16][N:15]=[C:14]([C:13]([F:22])([F:12])[F:21])[CH:19]=2)=[C:3]([CH:6]=1)[C:4]#[N:5])=[O:11]

Participants

Reactant 2

HCID 27695822-Fluoro-5-formylbenzonitrile

HCID 178516505HCID 178516505, compound

Product 1

HCID 86724169Benzonitrile, 5-formyl-2-[[2-(trifluoromethyl)-4-pyridinyl]oxy]-

Procedure

The title compound was prepared by a procedure similar to that described for D4 starting from 2-fluoro-5-formylbenzonitrile and 2-(trifluoromethyl)pyridine-4-ol.

Sources & evidence

ORD record: ord-04fb7140a49849d395b23190d1c2f272
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08975400B2

Reaction notes

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