1,4-Dioxane hydrochloride → 3-(1,3-Dioxolan-2-yl)propyl piperidine-4-carboxylate hydrochloride
Reaction equation
[ClH:1].O1CCOCC1.[N:8]1(C(OC(C)(C)C)=O)[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH2:18][CH2:19][CH:20]2[O:24][CH2:23][CH2:22][O:21]2)=[O:15])[CH2:10][CH2:9]1>>[ClH:1].[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH2:18][CH2:19][CH:20]2[O:21][CH2:22][CH2:23][O:24]2)=[O:15])[CH2:10][CH2:9]1Participants
3
Procedure
HCl-dioxane (4 M, 5 mL, 20 mmol) was added to 4-(3-(1,3-dioxolan-2-yl)propyl) 1-tert-butyl piperidine-1,4-dicarboxylate (0.71 g, 2.07 mmol) and the reaction mixture was stirred at RT for 1.5 hours. The solvent was evaporated at reduced pressure. The crude material was used directly without purification.
Workup
- customThe solvent was evaporated at reduced pressure
- customThe crude material was used directly without purification