Sodium Azide → (R)-1-azido-3-(3-(2-ethylbutoxy)phenyl)propan-2-ol

HRID 875538Notes

Reaction equation

HRID 875538 reaction equation
Cl[CH2:2][C@H:3]([OH:18])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:12][CH:13]([CH2:16][CH3:17])[CH2:14][CH3:15])[CH:6]=1.[N-:19]=[N+:20]=[N-:21].[Na+]>>[N:19]([CH2:2][C@H:3]([OH:18])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:12][CH:13]([CH2:16][CH3:17])[CH2:14][CH3:15])[CH:6]=1)=[N+:20]=[N-:21]

Participants

3

Reactant 2

HCID 33557Sodium AzideHCID 67316767(R)-1-chloro-3-(3-(2-ethylbutoxy)phenyl)propan-2-ol

Product 1

HCID 86637619(R)-1-azido-3-(3-(2-ethylbutoxy)phenyl)propan-2-ol

Procedure

Treatment of (R)-1-chloro-3-(3-(2-ethylbutoxy)phenyl)propan-2-ol with sodium azide following the method used in Example 66 gave (R)-1-azido-3-(3-(2-ethylbutoxy)phenyl)propan-2-ol which was used without further purification.

Sources & evidence

ORD record
ord-15d36ccf367d4f54a2c77524bbd2f145
Source dataset
uspto-grants-2015_03
Patent number
US08981153B2

Reaction notes

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