(7-Cyclopentyl-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol → HCID 58299552, compound
Reaction equation
[CH:1]1([N:6]2[C:10]3[N:11]=[C:12]([S:15][CH3:16])[N:13]=[CH:14][C:9]=3[CH:8]=[C:7]2[CH2:17][OH:18])[CH2:5][CH2:4][CH2:3][CH2:2]1>ClCCl.[O-2].[O-2].[Mn+4]>[CH:1]1([N:6]2[C:10]3[N:11]=[C:12]([S:15][CH3:16])[N:13]=[CH:14][C:9]=3[CH:8]=[C:7]2[CH:17]=[O:18])[CH2:2][CH2:3][CH2:4][CH2:5]1Participants
4
Procedure
Manganese dioxide (5.56 g, 64.0 mmol) was added to a solution of compound 228 (3.37 g, 12.8 mmol) in dichloromethane (250 mL). After 16 h, the reaction contents were filtered through Celite and organics were removed in vacuo to provide compound 229 (3.10 g, 92.7% yield).
Workup
- customthe reaction contents
- filtrationwere filtered through Celite
- customorganics were removed in vacuo
Sources & evidence
- ORD record
- ord-76831ab6e44746889d4eb1417e1c4f66
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08980903B2
Reaction notes
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