Ammonia → 7-Nitroquinazolin-4-amine

HRID 876606

Reaction equation

HRID 876606 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH3:15]>CO>[N+:12]([C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH2:15])=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1)([O-:14])=[O:13]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 8306804-Chloro-7-nitroquinazoline

Product 1

HCID 136977987-Nitroquinazolin-4-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1.6 g of 4-chloro-7-nitroquinazoline in 50 ml 7N ammonia in methanol was stirred overnight at rt and concentrated to dryness. The solid was suspended in water, filtered, rinsed with water followed by ether and dried overnight in vacuum oven to provide 0.98 g of 7-nitroquinazolin-4-amine (compound 98-2).

Workup

  1. concentrationconcentrated to dryness
  2. filtrationfiltered
  3. washrinsed with water
  4. customdried overnight in vacuum oven

Sources & evidence

ORD record
ord-1bcd3184a8ff4d60b219145e85c3fa70
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Linked notes

Loading…