Morpholine → 4-(6-Chloropyrimidin-4-yl)morpholine

HRID 876665

Reaction equation

HRID 876665 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:7]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 709434,6-Dichloropyrimidine

Product 1

HCID 7960704-(6-Chloropyrimidin-4-yl)morpholine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

45.0 g (302.1 mmol) 4,6-dichloropyrimidine are initially introduced into 450 ml water. 26.3 g (302.1 mmol) morpholine are added and the mixture is stirred at 90° C. for 16 h. Thereafter, it is cooled to 0° C. and the precipitate formed is filtered off. The precipitate is washed once with 50 ml water and dried in air.

Workup

  1. temperatureThereafter, it is cooled to 0° C.
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. washThe precipitate is washed once with 50 ml water
  5. customdried in air

Sources & evidence

ORD record
ord-b2b24157349e445d9ebbf6add1643c01
Source dataset
uspto-grants-2015_03
Patent number
US08987261B2

Linked notes

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