Ethanol → Ethyl 4-methyl-1H-1,2,3-triazole-1-acetate
Reaction equation
[CH3:1][C:2]1[N:3]=[N:4][N:5]([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=1.[CH2:11](O)[CH3:12]>S(=O)(=O)(O)O>[CH2:11]([O:9][C:8](=[O:10])[CH2:7][N:5]1[CH:6]=[C:2]([CH3:1])[N:3]=[N:4]1)[CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2.0 g (14.2 mmol) (4-methyl-1H-1,2,3-triazol-1-yl)acetic acid are dissolved in 30 ml ethanol and 10 drops of conc. sulfuric acid are added. The reaction mixture is stirred at RT for 16 h. For working up, the mixture is concentrated in vacuo, ethyl acetate is added to the residue and the suspension is washed with half-concentrated sodium bicarbonate solution. The organic phase is dried over magnesium sulfate, the solvent is removed completely on a rotary evaporator and the solid is dried in vacuo.
Workup
- concentrationthe mixture is concentrated in vacuo, ethyl acetate
- additionis added to the residue
- washthe suspension is washed with half-concentrated sodium bicarbonate solution
- dry with materialThe organic phase is dried over magnesium sulfate
- customthe solvent is removed completely on a rotary evaporator
- customthe solid is dried in vacuo
Sources & evidence
- ORD record
- ord-492501e079c34d3d83b1b6b183a6204b
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08987261B2
Reaction notes
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