Benzyl 4-((dimethylphosphinoyl)methyl)piperazine-1-carboxylate → 1-[(Dimethylphosphoryl)methyl]piperazine
Reaction equation
[CH3:1][P:2]([CH2:5][N:6]1[CH2:11][CH2:10][N:9](C(OCC2C=CC=CC=2)=O)[CH2:8][CH2:7]1)([CH3:4])=[O:3]>[Pd].CO>[CH3:4][P:2]([CH2:5][N:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)([CH3:1])=[O:3]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a flask was charged with benzyl 4-((dimethylphosphinoyl)methyl)piperazine-1-carboxylate (200 mg) and 10% palladium on carbon in methanol (20 mL). The mixture was stirred at room temperature under H2 atmosphere. The mixture was filtered through Celite and all solvents were removed under reduced pressure to give a white crystalline solid, which was used without further purification. LCMS ESI(+) m/z: 177 (M+1).
Workup
- filtrationThe mixture was filtered through Celite
- customall solvents were removed under reduced pressure
- customto give a white crystalline solid, which
- customwas used without further purification
Sources & evidence
- ORD record
- ord-3433a2443b704798bda5efe04195b433
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08987284B2
Reaction notes
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