Triethylamine → 2-(4-tert-Butylphenyl)-N-((3,4-difluorophenyl){1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-4-yl}methyl)acetamide

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Reaction Steps

To a 50 ml round bottom flask equipped with a magnetic-stir bar were added (3,4-difluorophenyl){1-[(trimethylsilyl)methyl]-1H-1,2,3-triazol-4-yl}methanaminium chloride (0.500 g, 1.502 mmol), 4-tert-butylphenylacetic acid (0.289 mg, 1.502 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.288 g, 1.502 mmol), 1-hydroxy-7-azabenzotriazole (0.204 mg, 1.502 mmol) and triethylamine (0.629 ml, 2.253 mmol) into 10.0 ml of CH2Cl2. The resulting solution was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and the two layers were separated. The aqueous layer was extracted with CH2Cl2. The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuum. Purification by preparative HPLC (20-90% CH3CN/H2O over 30 min, 0.05% added TFA, C18 column) to afford 0.536 g (67%) of the title compound. 1H NMR (CDCl3, 400 MHz) δ 7.347 (m, 2H), 7.190 (m, 3H), 7.040 (m, 2H), 6.970 (m, 2H), 6.223 (d, J=7.60 Hz, 1H), 3.852 (ABq, J=15.29 Hz, 2H), 3.580 (s, 2H), 1.305 (s, 9H), 0.125 (s, 9H). ES-MS [M+1]+: 471.2.

Provenance & Evidence