HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-3-(trifluoromethyl)benzoic acid → 4,N-Dimethyl-N-(4-o-tolyl-pyridin-3-yl)-3-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-3-(trifluoromethyl)benzoic acid | HCID 2775592 | — |
| Reactant | N-methyl-4-o-tolylpyridin-3-amine | HCID 18403336 | — |
| Product | 4,N-Dimethyl-N-(4-o-tolyl-pyridin-3-yl)-3-trifluoromethyl-benzamide | HCID 60197696 | — |
Reaction Steps
The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 4-methyl-3-trifluoromethyl-benzoic acid (CAS RN 261952-01-6) after a reaction time of 90 hours. Grey solid (32%). MS (ESI): m/z=385.15 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-f0848890fd14425ca24be45b1ff70017 |
| Source note | uspto-grants-2015_03 |