1-Butanol → Butyl ethyl(2-hydroxyethyl)phosphinate
Reaction equation
[CH2:1]([P:3]([CH2:6][CH2:7][OH:8])(=[O:5])[OH:4])[CH3:2].[CH2:9](O)[CH2:10][CH2:11][CH3:12].O>C1(C)C=CC=CC=1>[CH2:1]([P:3]([CH2:6][CH2:7][OH:8])(=[O:4])[O:5][CH2:9][CH2:10][CH2:11][CH3:12])[CH3:2]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
414 g (3 mol) of ethyl(2-hydroxyethyl)phosphinic acid (produced as in Example 8) are at 85° C. dissolved in 400 ml of toluene and admixed with 888 g (12 mol) of butanol. At a reaction temperature of about 100° C., the water formed is removed by azeotropic distillation to leave 500 g (86% of theory) of butyl ethyl(2-hydroxyethyl)phosphinate.
Workup
- customare at 85° C.
- customis removed by azeotropic distillation
Sources & evidence
- ORD record
- ord-748250f50db64502a1985fc3cb67ea96
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08987490B2
Reaction notes
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