2-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878953Notes

Reaction equation

HRID 878953 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[CH2:4]Br.[CH2:14]([N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([CH2:30][C:31]([OH:33])=[O:32])[CH:28]=2)[CH:23]=[CH:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[CH2:4][N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([CH2:30][C:31]([OH:33])=[O:32])[CH:28]=2)[CH:23]=[CH:22]1.[CH2:14]([N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([CH2:30][C:31]([OH:33])=[O:32])[CH:28]=2)[CH:23]=[CH:22]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 27375732-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzeneHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 681837762-{1-[2-fluoro-6-(trifluoromethyl)benzyl]-1H-indole-6-yl}acetic acid

Procedure

The titled compound (16 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 2-fluoro-6-(trifluoromethyl)benzyl bromide according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-6261786e14a242bb84de205d3a9042b2
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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