4-Ethoxyphenol → 2-Bromo-4-ethoxyphenol

HRID 879986

Reaction equation

HRID 879986 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)[CH3:2].[Br:11]Br>C(Cl)(Cl)Cl>[Br:11][C:8]1[CH:9]=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=[CH:6][C:7]=1[OH:10]

Participants

4

Reactant 2

HCID 121504-EthoxyphenolHCID 24408Bromine

Product 1

HCID 230482822-Bromo-4-ethoxyphenol

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 4-(ethyloxy)phenol (Commercial eg Aldrich) (1.0 g) in chloroform (5 ml) cooled to 0° C. was added bromine (1.26 g) dropwise over 20 min. The resulting mixture was stirred at 25 C for 2 h, before washing sequentially with aqueous sodium bicarbonate, and brine. The organics were dried over sodium sulphate, filtered and concentrated in vacuo to yield the title compound, 1.8 g

Workup

  1. washbefore washing sequentially with aqueous sodium bicarbonate, and brine
  2. dry with materialThe organics were dried over sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4c44dc31bdd64395a0330d2f20d4f8a3
Source dataset
uspto-grants-2015_03
Patent number
US08993560B2

Linked notes

Loading…