7-Bromoisoquinolin-3-amine → 3-Aminoisoquinoline-7-carboxylic acid
Reaction equation
FC(F)(F)[C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[CH:6]=[C:7]2[C:11]=1N[N:9]=[CH:8]2.BrC1C=C2C([CH:22]=[C:23](N)[N:24]=C2)=CC=1>>[NH2:24][C:23]1[N:9]=[CH:8][C:7]2[C:11]([CH:22]=1)=[CH:3][CH:4]=[C:5]([C:12]([OH:14])=[O:13])[CH:6]=2Participants
3
Procedure
The title compound was prepared by a method analogous to that described in Steps 3-4 of Intermediate 21, using 7-bromoisoquinolin-3-amine. +ESI (M+H) 189.2; 1H NMR (400 MHz, CD3OD, δ): 8.87 (s, 1H), 8.52 (d, J=0.78 Hz, 1H), 7.98 (dd, J=8.78, 1.76 Hz, 1H), 7.54 (d, J=8.78 Hz, 1H), 6.77 (s, 1H).
Sources & evidence
- ORD record
- ord-40aae240cfb6491aa15a0fc44c1785ff
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08993586B2
Reaction notes
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