2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-methyl-5-{[2-(3-oxomorpholin-4-yl)ethoxy]methyl}pyridin-2-yl)amino]thiophene-3-carboxamide

HRID 88179

Reaction equation

HRID 88179 reaction equation
[Cl:22][c:23]1[cH:24][cH:25][c:26]([CH2:30][O:31][CH2:32][CH2:33][N:34]2[C:35](=[O:40])[CH2:36][O:37][CH2:38][CH2:39]2)[c:27]([CH3:29])[n:28]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:23]1[cH:24][cH:25][c:26]([CH2:30][O:31][CH2:32][CH2:33][N:34]2[C:35](=[O:40])[CH2:36][O:37][CH2:38][CH2:39]2)[c:27]([CH3:29])[n:28]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595259664-{2-[(6-Chloro-2-methylpyridin-3-yl)methoxy]ethyl}morpholin-3-one

Product 1

HCID 595256515-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-methyl-5-{[2-(3-oxomorpholin-4-yl)ethoxy]methyl}pyridin-2-yl)amino]thiophene-3-carboxamide

Sources & evidence

ORD record
ord-b7809a5e5b564119ba814883eaead799
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

Loading…